Abstract
strictive pattern was associated with significant reduction of BNP levels (12 mos: 130 ± 55 pg/ml vs baseline: 433±64 vs, p 150 msec. Patients were studied 449±219 days after continuous BVP. Thereafter, the biventricular mode was deac- tivated (Off) and patients were restudied after an equilibration period of 72 hours keeping all medications constant. The maximal rate of LV systolic pressure rise (dP/dt) was estimated by measuring the time interval between 1 and 3 m/sec on the mitral regurgitation (MR) continuous-wave Doppler spectrum. MR severity was assessed by the color Doppler jet area and the proximal isovelocity surface area (PISA) method. In the BVP mode, systolic blood pressure (122±17 vs. 106±23 mm Hg, P<0.001) and LV ejection fraction (29±12 vs. 25±10%, P<0.01) were higher, LV diastolic filling time was longer (426±67 vs. 395±65 msec, p<0.01), and heart rate was not different (71± 5v s. 68±5/min, NS).
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