Abstract
Background: Coagulopathy is an important clinical feature of Coronavirus Disease 2019 (COVID-2019) associated with severe conditions, making D-dimer useful as a prognostic tool to predict severity and mortality of COVID-19. Hypertension also caused elevated D-dimer levels. Objective: This study aims to compare D-dimer levels in hypertensive and non-hypertensive COVID-19 patients. Methods: Cross-sectional study was conducted on 96 adult COVID-19 patients admitted between October 2020 and January 2021. Patients with diabetes mellitus, pregnancy/postpartum and malignancy were excluded. D-dimer levels were compared using independent T-test or Mann-Whitney test. Age, sex and severity of COVID-19 were adjusted using subgroup analysis. Result: 96 COVID-19 patients who were mostly (56.8%) males with 57 subjects (71.25%) younger than 60 years old were included in the analysis. 48 (50%) subjects were hypertensive. Median D-dimer levels of hypertensive and non-hypertensive COVID-19 patients were 1,021.0 (154.0–10,000) and 503.5 (204.0–2,798.0) respectively. The difference between median D-dimer levels of hypertensive and non-hypertensive was significant (p = 0.004). The difference, however, was only found in subjects younger than 60 years old and those with mild symptoms, indicating that age and severity may contribute to D-dimer level. Conclusion: D-dimer level was significantly higher in hypertensive COVID-19 patients compared to non-hypertensive patients. Age and disease severity also affect D-dimer levels in COVID-19 patients
Published Version
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