Abstract
Skin is the primary interface with the external environment. To evaluate the impact of external factors like sun exposure on the cutaneous ecosystem (skin-sebum-microbiota), it has to be studied as a whole to understand how they interact with each other. We developed a reconstructed human epidermal model colonized with human microbiota and sebum to reproduce the complexity of the skin ecosystem. This in vitro model was exposed to simulated solar radiation (SSR). A new SPF50+ photoprotective system containing a specific combination of four sun filters (TriAsorB, Tinosorb S, Uvinul T150 and Uvinul A+) and affording a broad spectrum UVB+A photoprotection, was evaluated on this in vitro model.
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