536: Progesterone inhibits TNFα-induced apoptosis in fetal membranes by altering expression of pro- and anti-apoptotic proteins: implications for inflammation-mediated preterm birth

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Progesterone supplementation prevents PTB in some high-risk women, but its mechanism of action is unknown. One third of PTB is associated with intraamniotic inflammation (IAI). We have previously shown that progesterone inhibits inflammatory cytokine (TNFα)-induced apoptosis in fetal membranes (Luo et al. Reprod Sci 2010;17:532). This study investigates the molecular mechanisms responsible for this progesterone-mediated inhibition.