532-P: Effect of ABC Control of Diabetes on the Prevalence of Chronic Kidney Disease in Patients with Type 2 Diabetes from Tibet in China

Abstract

Aim: To investigate the effect of ABC control of diabetes (A: HbA1c, B: blood pressure and C: LDL-C) on the prevalence of chronic kidney disease (CKD) in patients with type 2 diabetes (T2D) from Tibet based on electronic medical records. Methods: Patients (aged 18-79 years) documented from 2014 to 2018 were enrolled. Control criteria were defined base on the 2017 Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes: HbA1c < 7.0%, blood pressure <130/80 mmHg and LDL-C <1.8 mmol/L with coronary heart disease (CHD) and 2.6 mmol/L without CHD. CKD was defined as eGFR <60 ml/min per 1.73 m2 and/or urinary albumin/creatine ratio ≥ 30 mg/g. Patients were divided into four groups according to ABC control. Results: A total of 1999 patients were enrolled. The mean (SD) age was 55.2 (10.5) years. The median diabetic duration was 7.0 (range: 0.1-32) years and 43.9% patients were female. As shown in Figure 1, the prevalence of CKD has increased in parallel with the bad control of ABC (P<0.001). Compared with patients achieved all three targets, patients with none of target achieved had a 2.70-fold (95% CI: 1.25-5.86, P = 0.012) higher risk for CKD after adjusted for age, gender and diabetic duration. Conclusions: The achievement of ABC target was associated with the prevalence of CKD. More intensive T2D management is warranted to prevent the development of CKD in this population. Disclosure Z. Chenghui: None. W. Yunhong: None. W. Suyuan: None. L. Mingxia: None.