Abstract
Cortisol activity at the glucocorticoid receptor (GR) contributes to chemotherapy resistance by suppressing apoptotic pathways that taxanes utilize, and high tumor GR expression is associated with poor chemotherapy response in ovarian cancer. A phase 2 ovarian cancer study (NCT03776812) demonstrated the clinical benefit of adding relacorilant (RELA), a selective GR modulator, to nab-paclitaxel (NP) compared to NP alone. We present biomarker analyses from this study.
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