Abstract
The tribe Chelidonieae of family Papaveraceae is a botanical source of various medicinal components, which has been commonly used in traditional Chinese medicine for many centuries. Increasing interest in Chelidonieae pharmaceutical resources has led to additional discoveries of alkaloids, flavonoids, terpenoids, glycosides, and many other compounds in various Chelidonieae species and to investigations on their chemotaxonomy, molecular phylogeny, and pharmacology. In continuation with our studies on Chelidonieae pharmacophylogeny, we review the phytochemistry, pharmacology, chemotaxonomy, and molecular phylogeny of Chelidonieae and their relevance to drug efficacy. Literature search is used to characterize the global scientific endeavor in the versatile technologies being used. The most remarkable pharmacological effect of both Chelidonieae compounds and extracts is the anticancer activity. The congruence between chemotaxonomy and molecular phylogeny is revealed and the evolution of plant alkaloid biosynthesis discussed. There is a lack of genomic, transcriptomic, and metabolomic studies of Chelidonieae. For both the sustainable utilization of Chelidonieae pharmaceutical resources and finding novel compounds with potential clinical utility, systems biology and omics technologies will play an increasingly important role in future medicinal research involving bioactive compounds of Chelidonieae.
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