Abstract
BackgroundSerotonin (5-HT), a monoaminergic neurotransmitter, involves in the regulation of many physiological functions. In the present study, the effects of 5-hydroxytryptophan (5-HTP), the precursor of 5-HT, on lipid metabolism and intestinal immune function in broiler chickens were investigated in chickens.MethodsTwo hundred broilers were divided randomly into two groups and fed separately with a corn-soybean basal diet (CD) or the basal diet supplemented with 0.2% 5-HTP.ResultsThe results showed that 5-HTP reduced (P < 0.05) feed intake and the abdominal fat pad weight. 5-HTP treatment tended to upregulate the mRNA level of adiponectin receptor 1 (ADP1R) and ADP2R in abdominal fat but had no significant influence on their protein levels (P > 0.05). In 5-HTP-chickens, lipopolysaccharide exposure decreased secretory immunoglobulin A (sIgA) concentrations in serum and the duodenal contents. Expression of mRNA encoding interleukin (IL), tumor necrosis factor-α (TNF-α), and transforming growth factor-β (TGF-β) decreased after 5-HTP treatment; however, LPS increased expression significantly in 5-HTP-treated chickens compared with CD chickens. In 5-HTP-chickens, the phosphorylation of mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) were reduced, but the phosphorylation of ribosomal p70S6 kinase (p70S6K) was increased in the duodenum.ConclusionIn summary, the result suggests that dietary 5-HTP supplementation reduces accumulation of abdominal fat and is beneficial to intestinal immune function.
Highlights
Serotonin (5-HT) is a monoaminergic neurotransmitter that modulates the function of the central and peripheral nervous systems (Veenstra-VanderWeele et al, 2000)
The feed intake during the entire experiment period was decreased by 5-HTP treatment (P < 0.05). 5-HTP treatment led to reduced Body weight (BW) gain in the period of 8– 21 days of age (P = 0.050) and a trend toward reduced BW gain (P = 0.056) from 8 to 35 days of age, but had no significant influence in the period of 22–35 days of age (P > 0.05, Table 3)
5-HTP was supplemented in the broiler diet for 28 days and the zootechnical performance was measured at 35 days of age, which is in the period of maximum growth rate of body weight body of modern strain of broilers (Scheuermann et al, 2003)
Summary
Serotonin (5-HT), a monoaminergic neurotransmitter, involves in the regulation of many physiological functions. The effects of 5hydroxytryptophan (5-HTP), the precursor of 5-HT, on lipid metabolism and intestinal immune function in broiler chickens were investigated in chickens
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