Abstract
By the use of new more specific psychoactive drugs data are presented which add support for the role of 5-hydroxxtryptamine (5-HT) in the control of sexual receptivity in female mammals. Thus the 5-HT uptake blockers GEA654 and H102/09 and the 5-HT releasing agent PTR 17402 totally inhibit the receptivity induced by estrogen and progesterone. The induction of receptivity by the highly specific 5-HT receptor blocker metherzoline is also significant. These effects are correlated with the actions of the drug on extensor reflex activity and 5-HT turnover. Some of the hallucinogenic compounds stimulate pre- and postsyn ptic 5-HT receptors at low dosage but as dosage increases sexual activity is inhibited. This was 1st observed with D-LSD. Other hallucinogenic indole-alkylamines have been shown to have similar effects. Results point to the involvement of 5-HT on sexual receptivity but none define the mechanism of action of progesterone nor on which component of the 5-HT-containing neural system it acts.
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