Abstract
The involvement of serotonin (5HT) and γ-aminobutyric acid (GABA) in the control of estrous sexual receptivity has been investigated in the cyclic female rat. (1) When injected at 1300 hr on proestrus parachlorophenylalanine ( pCPA) specifically increased sexual receptivity as expressed by the number of receptive females between 1800 and 1900 hr and simultaneously depressed 5HT turnover. (2) A specific decrease in blood progesterone (P) concentration was observed on proestrus at 1530 hr in females treated with pCPA on proestrus at 1300 hr. (3) When injected on proestrus at 1730 hr dipropylacetate (DPA) induced a decrease in sexual receptivity between 1830 and 1900 hr in both intact and bulbectomized females but it depressed the lordosis quotient only in unoperated females. (4) An increase in the amount of γ-aminobutyric acid (GABA) in the olfactory bulbs and in the hypothalamus was noted at 1845 hr in DPA treated females. A significant decrease in the olfactory bulb GABA content occurred from 1845 to 2245 hr on proestrus. (5) The results are in favor of an involvement of 5HT and GABA in the control of the timing of sexual receptivity by the olfactory bulbs in the rat. They also suggest that interactions between P and 5HT are implicated in the control of sexual receptivity in the cyclic female rat.
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