Abstract
The study aims to replicate the previous found association of 5-HTTLPR and inertia of negative affect in daily life of adolescents and young adults. Data of 877 adolescents (aged 14–21 years) of the Behavior and Mind Health (BeMIND) study (epidemiological cohort study, Dresden, Germany) were genotyped for 5-HTTLPR/rs25531, grouped into SS/SLG/SLA/LGLA/LGLG vs. LALA, and provided ratings on negative affect items, depression and anxiety (Patient-Reported Outcomes Measurement Information System) eight times a day over 4 days. Multilevel regression models did not reveal an association of 5-HTTLPR genotype and inertia of negative affect, nor associations with inertia of anxiety or depression. Inertia of negative affect seems not to be a psychological mechanism through which 5-HTTLPR acts on psychopathology.
Highlights
ObjectivesThe aim of the present study was to replicate this finding by van Roekel et al (2018) using a larger population sample of adolescents and young adults
We investigated the relationship between 5-HTTLPR/ rs25531 genotype and the carry over effect of affect from one assessment to the one, namely inertia (Kuppens et al 2010), with regard to the negative affect scale using multilevel regression modeling to account for the multilevel structure of the data
The Slope sections show the effect of the covariate on the slope of the t−1 affect score, i.e. the regression coefficients of the interaction between covariate and person mean-centered t−1 affect score in predicting t affect score b regression coefficient, CI confidence interval mentioned above, the results of the random slope model are used for interpretation. This Ecological Momentary Assessment (EMA) study conducted in a general population sample of adolescents and young adults did not confirm the previously by van Roekel et al (2018) reported association between the 5-HTTLPR/rs25531 S allele and inertia of negative affect
Summary
The aim of the present study was to replicate this finding by van Roekel et al (2018) using a larger population sample of adolescents and young adults. The overall aim of the study is to investigate developmental trajectories and risk factors of mental and behavioral disorders
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