Abstract
5-HT 3 receptors are widely distributed in the CNS and PNS where they participate in a variety of physiological processes. Native 5-HT 3 receptors in the CNS display functional and pharmacological heterogeneity, suggesting the existence of multiple receptor subunits. However, recent evidence suggests that of the two known subunits only the 5-HT 3A receptor subunit (and not the 5-HT 3B receptor subunit) is functionally present in the CNS. The molecular makeup of the 5-HT 3 receptor therefore remains an open question.
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