Abstract
2-Methyl-5-Hydroxyethylaminophenol is used in oxidative hair dyes as a coupler at concentrations ranging from ≤ 0.1 to 5.0%. Only slight absorption was observed in skin studies. The LD50 of the ingredient in mice ranged from 2.5 to 3.84 g/kg. The ingredient was less of an irritant when tested alone than when tested in hair dye formulations. The compound is neither a mutagen nor a teratogen. 2-Methyl-5-Hydroxyethylaminophenol was classified as a nonirritant and weak sensitizer in human studies. Precautionary statements and instructions for patch testing are required on the label when used in oxidative hair dyes. On the basis of the available data included in the report, 2-Methyl-5-Hydroxyethylaminophenol is considered to be safe for use in the present practices of use and concentrations.
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