Abstract
The discovery of CP-161,242 (5-cyano-1-[3-(N-methylpyrrolidin-2R-ylmethyl)indol-5-yl]benzimidazole), a potent, selective, orally active central serotonin (5-HT 1D) agonist [IC 50 (binding) = 1.3 nM, EC 50 (inhibition of adenylate cyclase) = 42 pM] and benzodiazepine ligand [ IC 50 ( binding) = 3.3 nM], is presented.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have