Abstract
Singly, sulfonamide and chalcone are well known pharmacophoric groups which have several pharmaceutical applications for a variety of diseases. Combination of two or more pharmacophoric groups can enhance the probability of discovering new lead compounds, especially if closely related activities are involved. The title compound, C23H21NO4S, was prepared in order to investigate its potential clinical application. It shows an interesting molecule that shows a V-shaped molecular structure formed by sulfonamide and chalcone arms. The chalcone group is quasi-planar and the sulfonamide aromatic ring is almost perpendicular to the mean plane of the chalcone. An infinite zigzag chain parallel to the crystallographic axis [001] results from intermolecular N—H⋯O hydrogen bonds and keeps the molecules perfectly stacked in this direction.
Published Version
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