Abstract
1,2,3-Trichloropropane (TCP) is a chlorinated hydrocarbon that was historically used as an industrial solvent and a degreasing agent. TCP is utilized as an intermediate in the production of polymer cross-linking agents, pesticides, and glycerol. In its pure form, TCP is a colorless to yellow liquid with limited solubility in water, a strong chloroform-like odor, moderate volatility, and high flammability. In the agrochemical industry, TCP is formed via the manufacture of dichloropropene-derived nematicides (pesticides used to kill parasitic nematodes), and it is also present as an impurity in these soil fumigants. As a result, application of these products has produced significant atmosphere, soil, and groundwater contamination, which in turn can induce various health problems in wildlife and humans. The toxicological effects of TCP depend on dose and duration, but can range from kidney and liver damage to tumors and cancers.
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