Abstract
4D Flow and 2D PC MRI: impact of volumetric coverage and three-directional velocity encoding on quantification of aortic hemodynamics
Highlights
The accurate assessment of arterial blood flow is crucial for the diagnosis and management of patients with cardiovascular disease
We studied 15 healthy volunteers (51 ± 19 yrs; 11 men) with MRI (1.5T MAGNETOM Aera, Siemens). 4D flow MRI was acquired in a sagittal oblique 3D volume covering the thoracic aorta (free breathing; spatial resolution = 3.1 × 2.3 × 2.5 mm3; temporal resolution = 39.2 ms)
All 2D CINE PC and 4D flow MRI data were preprocessed to correct for Maxwell terms, velocity aliasing and eddy currents (Figure 1). 4D flow MRI data analysis included the 3D segmentation of the aorta (Mimics, Materialise) with a plane placed orthogonal to the aortic centerline (Ensight, CEI) and coregistered to the scanner coordinates of the 2D slices used for the 2D CINE PC MRI
Summary
The accurate assessment of arterial blood flow is crucial for the diagnosis and management of patients with cardiovascular disease. Our aim was to systematically compare three phase-contrast (PC) MRI sequences for the quantification of aortic hemodynamics, including: 1) 2D time-resolved (CINE) PC MRI with one-directional through-plane (2D-1dir) velocity encoding; 2) 2D CINE PC MRI with three-directional (2D-3dir) velocity encoding; 3) 4D flow MRI with full volumetric coverage of the aorta and three-directional velocity encoding
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