Abstract
Since there are only a few tissue markers used in the routine histopathology of melanoma, there is an unmet need for novel protein discovery for both prognostic and predictive implications. Our introduction of formalin-fixed paraffin-embedded (FFPE) melanoma samples provides new opportunities to understand the progression of melanoma. The study was based on the previously archived 175 human FFPE primary and metastatic melanoma samples which were annotated by an enhanced pathology validation for mutated BRAF protein and analyzed by high-resolution mass spectrometry.
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