Abstract
This chapter discusses the use of deuteration in the study of water's role in biosystems and focuses on the investigations on the structure and function of membrane in excitable biosystems. Deuteration is a very good nondestructive method to study water involvement both in the structure and in the molecular mechanisms of various functions of excitable biosystems. Water distribution in a tissue and its dependence on the state of tissue and/or of its cellular and intracellular macro- and multimolecular structures are revealed by deuteration kinetics. An excessive stress on the tissue energetic equipment upon deuteration is recorded in all the studies of excitable biosystems. This stress can be because of substantial enhancement of energy demand in deuterated biosystems and the absence of protons indispensable to the processes of ATP production and delivery. All D2O effects on excitable biosystems are disclosed to be partially reversible. Function resumption becomes possible only on total rehydration of the systems.
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