Abstract
It is proposed that the thyroid hormones act on cellular membranes altering the level of unsaturation of the membrane fatty acids. These changes in membrane composition affect membrane fluidity and hence membrane function. Many of the effects of the thyroid hormones can then be explained as secondary results of a change in membrane structure and function. Such an action also explains the differences in membrane composition and membrane function between homeotherms and poikilotherms. These hormones are also involved in the tolerance of low temperature during hibernation.
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