Abstract
Asthma is a complex heterogeneous disease, and as with most human diseases, investigation into the underlying molecular mechanisms has led to the development of animal models that replicate key features of the disease, including inflammation, airway hyperreactivity and airway remodeling. Historically, these models have focused on the generation of type 2 immune pathways, but with the recognition that asthma, as a disease entity, encompasses multiple different clinical phenotypes, mouse models that reflect this complexity are required. This chapter focuses on ways in which disease parameters can be modeled and manipulated in vivo.
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