Abstract
Antibiotics are commonly used to control, treat or prevent bacterial infections, however bacterial resistance to all known classes of traditional antibiotics has significantly increased in the last decades especially in hospitals rendering certain therapies ineffective. To limit this emerging public health problem there is a need to develop non-invasive, non-toxic and novel antimicrobial strategies that act more efficiently and faster than the current antibiotics, to which pathogens will not easily develop resistance. One of these methods is Antibacterial Photodynamic Therapy (aPDT). This review focuses on the application of porphyrins in the photo-inactivation of bacteria. Mechanisms of bacterial resistance and some of the current ‘greener’ methods of synthesis of meso-phenyl porphyrins are discussed. In addition, significance and limitations of aPDT are also discussed. Furthermore, we also elaborate on the current clinical applications and the future perspectives and directions of this non-antibiotic therapeutic strategy in combating infectious diseases.
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