Abstract
Cutaneous squamous cell carcinoma (cSCC) possesses metastatic potential and in metastatic case the prognosis is poor. At present, there are no established biomarkers for assessment of metastasis risk or prognosis of primary cSCC. Cancer-associated fibroblasts (CAFs) promote the progression of cancer, but there is limited evidence of their role in cSCC. Here, we have examined the potential of CAF markers in the assessment of metastasis risk and prognosis of cSCC. We used multiplexed fluorescence immunohistochemistry to profile CAF landscape in metastatic and non-metastatic primary human cSCCs, actual metastases, and in premalignant and benign epidermal lesions.
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