Abstract
Cutaneous squamous cell carcinoma (cSCC) possesses metastatic potential and in metastatic cases the prognosis is poor. At present, there are no established metastasis risk-associated or prognostic biomarkers for cSCC. Cancer-associated fibroblasts (CAFs) promote the progression of cancer, but there is limited evidence for their role in cSCC. We have examined the potential of CAF-associated biomarkers in the assessment of metastasis risk and prognosis of cSCC. We used multiplex immunohistochemistry to profile CAF landscape in tissue microarrays containing metastatic (n=33) and non-metastatic (n=146) primary human cSCCs, metastases (n=13), cSCC in situ (cSCCIS) (n=59), actinic keratoses (AK) (n=67), seborrheic keratoses (n=17) and normal skin (n=73).
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