Abstract
Clinical epidiomologic evidence suggests that magnesium sulfate used for preterm labor may ameliorate the risks of fetal neurologic injury. The biologic plausibility of this is poorly understood. Matrix metalloproteinases are complex zinc dependent enzymes. Matrix metalloproteinase -9 (MMP9) levels are elevated in preterm labor patients and in patients with preterm amniorrhexis. There is evidence that MMP9 may break down the blood brain barrier in humans, leading to a cytokine mediated cell injury.
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