Abstract
This chapter investigates the cytotoxic activity of natural killer (NK) cells, primarily in terms of its modulation by external factors, cytokines, and their receptors. The investigations were performed on 50 healthy controls and on 71 patients in different clinical stages of breast cancer. The sera of patients with different clinical stages of breast cancer were used for the investigation of their effect on NK cell activity of patients and controls, and it was shown that the sera of patients in early clinical stages had an enhancing effect on NK cell activity compared to control normal sera. The findings show that interleukin 2 (IL-2), tumor necrosis factor α (TNFα), and the sera of patients with localized breast cancer potentiate their cytotoxicity to a different degree, whereas sera of patients in advanced clinical stages of breast cancer, after dialysis and blocking monoclonal antibodies (mAbs) for TNF Rcs, decrease NK cell cytotoxicity.
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