Abstract
This chapter investigates the cytotoxic activity of natural killer (NK) cells, primarily in terms of its modulation by external factors, cytokines, and their receptors. The investigations were performed on 50 healthy controls and on 71 patients in different clinical stages of breast cancer. The sera of patients with different clinical stages of breast cancer were used for the investigation of their effect on NK cell activity of patients and controls, and it was shown that the sera of patients in early clinical stages had an enhancing effect on NK cell activity compared to control normal sera. The findings show that interleukin 2 (IL-2), tumor necrosis factor α (TNFα), and the sera of patients with localized breast cancer potentiate their cytotoxicity to a different degree, whereas sera of patients in advanced clinical stages of breast cancer, after dialysis and blocking monoclonal antibodies (mAbs) for TNF Rcs, decrease NK cell cytotoxicity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.