431: Predictors of neonatal and post-neonatal death among preterm infants born between 34-36 weeks’ gestation

Abstract

To examine the maternal factors associated with neonatal and post-neonatal death among preterm infants born between 34-36 weeks’ gestation. We conducted a retrospective cohort study of women with singleton, non-anomalous births in California from 2007 to 2011. We included live births between 34-36 weeks’ gestation. We categorized infant death into neonatal and post-neonatal death; neonatal death was defined as death occurring between 0-27 days after birth and post-neonatal death was 28-365 days after birth. We evaluated the association between neonatal and post-neonatal death with a variety of maternal socioeconomic and health characteristics to determine if different characteristics are associated with each. We only included variables in the multivariable logistic regression model if they were significantly different in bivariate analysis and excluded variables if they were collinear with others. Analyses were considered significant if the p-value was < 0.05. There were 150,241 live births between 34-36 weeks’ gestation, with 154 (0.1%) neonatal deaths and 230 (0.15%) post-neonatal deaths. Obese pre-pregnancy BMI and low prenatal care attendance were significantly associated with neonatal death (Table 1). Alternatively, Black race, overweight and obese pre-pregnancy BMI, low prenatal care attendance and chronic hypertension were significantly associated with post-neonatal death, while attending some college was protective (Table 2). We found that there are multiple variables that are associated with infant death among preterm infants born between 34-36 weeks’ gestation; however, there are differences between the predictors of neonatal and post-neonatal death, suggesting targeted interventions should be utilized.View Large Image Figure ViewerDownload Hi-res image Download (PPT)