Abstract
We previously developed an innovative reconstructed human epidermis (RHE) combining two main characteristics of Atopic Dermatitis (AD): an inflammatory medium (a cocktail of TNFa and interleukins IL-4, IL-13 and IL-31) and Staphylococcus aureus (S. aureus) surface colonization. We identified an extract of Castanea sativa leaves with potential protective properties against epidermal barrier defects. This was confirmed in vitro using the AD model and in vivo on a cohort of 22 volunteers with mild to moderate AD (EASI grade 3-11).
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