Abstract
Objective: This study compared the circadian variations in blood pressure (BP) and pulse rate (PR) in children (CD), middle aged (MA) people, and elderly (EL) people. Methods: CD (age, 9-10 years), MA subjects (age, 30-35 years) and EL subjects (age, 65-70 years) provided blood and urine samples and underwent 24-h ambulatory BP monitoring. Circadian variation patterns in their BP and PR were compared. The serum and urinary creatinine (SCr and UCr), urinary Na (UNa), and urinary K (UK) levels were measured to determine renal function and UNa and UK excretion values. None of the subjects had previously received any antihypertensive agents or other any medication. Results: The difference in the daytime and night time BP was highest in CD and lowest in EL subjects. The whole day PR was highest in CD and lowest in EL subjects. The non-dipper pattern prevalence was 24.4% in CD, 43.5% in MA subjects, and 78.6% in EL subjects. The UNa excretion value did not differ between the 3 groups. The UK excretion value was the lowest in the non-dipper EL subjects. Multiple regression analysis showed that the mean BP value was directly related with the SCr and UNa excretion values. Conclusion: The difference in the daytime and nighttime BP values in CD may be attributable to the elasticity of young blood vessels. Furthermore, potassium intake may be related to the elasticity of blood vessels in EL people.
Published Version
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