422 - Lipid Peroxidation and Antioxidant Defense System Changes in Mongoloids with Type 1 Diabetes Mellitus

Abstract

Background Numerous studies indicate the activation of free radical processes in different stages and in different types of diabetes. The impact of ethnic factors on the course of the disease is of particular interest. The aim of this study was investigation of the lipid peroxidation content components in Mongoloids with type 1 diabetes mellitus (T1DM). Methods The study included living in Eastern Siberia Mongoloid patients with (n = 38, mean age - 34,4 ± 1,9 years, duration of the disease - 12,05 ± 1,51 years). The T1DM diagnosis in all patients was confirmed by clinical and laboratory investigations. Severe comorbidities and severe diabetic complications were excluded. The average level of glycated hemoglobin in Mongoloids was 8,65±1.39%. The control group consisted of healthy individuals: Mongoloids with absence of family history for diabetes (n = 34, mean age 30,3 ± 1,3 years). Serum and hemolysate used as material for the study. Spectrophotometric and fluorometric methods used. Results In Mongoloid patients the diene conjugates level increased compared with the control group has been found (1.34-times higher , p Conclusion Changes in the system of POL-AOD in Mongoloid-patients are characterized by low intensity, which is probably due to the increased activity of the antioxidant defense system. These data are confirmed by clinical course of type 1 diabetes mellitus with a rare development of complications in Mongoloids of Eastern Siberia compared to average performance in all population and figures of European one.