Abstract
BACKGROUND: Near Infrared Spectroscopy (NIRS) combined with the method of partial jugular venous occlusion (JVO) has been introduced to measure cerebral venous saturation (CVSO2) at the bedside. As yet, the method has not been validated in the newborn brain. We aimed to validate the JVO procedure in a newborn lamb model using cerebral venous oxygen saturation in withdrawn superior sagittal sinus blood as the 'gold standard'. METHOD: Seven newborn lambs were anaesthetised and ventilated using 10–40% inspired oxygen to generate a range of oxygen saturations from normoxia (SPO2 > 95%) and hypoxia (SPO2 10% were included, mean difference (SD) betweeen SSSO2 and CVSO2 reduced to 2.7% (9.3%) with further improved correlation (r=0.9). CONCLUSION: The accuracy of NIRS with JVO in estimating CVSO2 varies according to the changes in cerebral venous blood volume induced by JVO. This critical aspect of the JVO technique needs to be taken into consideration in developing an accurate measurement in human infants.
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