419 THE IMPACT OF SERUM CYFRA 21-1 ON THE PROGNOSIS OF PATIENTS WITH UPPER URINARY TRACT UROTHELIAL CARCINOMA

Abstract

You have accessJournal of UrologyUrothelial Cancer: Upper Tract Tumors1 Apr 2010419 THE IMPACT OF SERUM CYFRA 21-1 ON THE PROGNOSIS OF PATIENTS WITH UPPER URINARY TRACT UROTHELIAL CARCINOMA Taisuke Suyama, Shigeki Kanbe, Koichi Nakajima, Hiroshi Hara, Koichi Nagao, and Nobuhisa Ishii Taisuke SuyamaTaisuke Suyama Ota-ku, Tokyo, Japan More articles by this author , Shigeki KanbeShigeki Kanbe Ota-ku, Tokyo, Japan More articles by this author , Koichi NakajimaKoichi Nakajima Tokyo, Japan More articles by this author , Hiroshi HaraHiroshi Hara Tokyo, Japan More articles by this author , Koichi NagaoKoichi Nagao Tokyo, Japan More articles by this author , and Nobuhisa IshiiNobuhisa Ishii Tokyo, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.489AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Although upper urinary tract urothelial carcinoma accounts for only approximately 5% to 7% of urothelial malignancies, its incidence has been increasing in the last 2 decades in the USA. In general, the prognosis for upper urinary tract urothelial carcinoma is worse than that for bladder tumors. Thus, specific prognostic indicators are needed to enable selection of optimal therapies. Previous reports show that pathological T stage, pathological grade, tumor location, lymph node involvement (LNI), lymphovascular invasion (LVI) and surgical procedure are prognostic factors for upper urinary tract urothelial carcinoma. However, all of these are postoperative factors. And to our knowledge, previous report shows that preoperative serum C-reactive protein (CRP) is a biomarker that can predict prognosis in patients with upper urinary tract urothelial carcinoma treated surgically. In the present study we examined the prognostic significance of serum CYFRA 21-1 status in patients with upper urinary tract urothelial carcinoma. METHODS We retrospectively reviewed the clinical records of 61 patients with upper urinary tract urothelial carcinoma. A serum CYFRA 21-1 level less than 3.5 ng/mL is considered normal. Actuarial survival curves were calculated using the Kaplan–Meier method. Differences between survival curves were then evaluated using the log-rank test. Multivariate analysis was performed using a Cox proportional-hazards model. RESULTS During a median follow-up of 29 months (range, 2-234 months), 30 patients (49.1%) died of the disease. Serum CYFRA 21-1 level was not elevated in 33 of the 61 patients (54.1%). The disease-specific survival rate in patients with a high serum CYFRA 21-1 level was significantly lower than in those without a high serum CYFRA 21-1 level (p<0.001). Multivariate analysis revealed that clinical and/or pathological N stage▫@and serum CYFRA 21-1 level were significant prognostic factor for disease-specific survival. CONCLUSIONS This study indicated that an elevation of serum CYFRA 21-1 predicts a poor survival in patients with upper urinary tract urothelial carcinoma. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e165 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Taisuke Suyama Ota-ku, Tokyo, Japan More articles by this author Shigeki Kanbe Ota-ku, Tokyo, Japan More articles by this author Koichi Nakajima Tokyo, Japan More articles by this author Hiroshi Hara Tokyo, Japan More articles by this author Koichi Nagao Tokyo, Japan More articles by this author Nobuhisa Ishii Tokyo, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...