Abstract
This chapter provides an overview of how the mechanism of phosphorylation-dependent regulation of smooth muscle was deduced. It describes how electron microscopic studies of the inhibited state provided a structural context to interpret over a decade of mutational studies on various regions of the smooth muscle myosin molecule (motor domain, light chains, coiled-coil rod). Unique features of the smooth muscle myosin molecule and of smooth muscle are highlighted, as well as the role that isoforms play in the plasticity of smooth muscles. Diseases caused by mutations in smooth muscle myosin are discussed.
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