Abstract
Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferation and aberrant differentiation of keratinocytes, inflammation in dermis and epidermis and leukocyte infiltration by a Th1-like cytokine pattern. An experimental mechanism-based in vitro model has been developed by using a novel multi-compartment reconstructed full-thickness skin (3C System by Episkin SA) and applying systemically a mixture of Th-1 cytokines (IL-17, IL-22 and TNFα) at defined concentration (1,5ng/ml each in 2 ml medium) for 48h.
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