410 ASSOCIATION OF GLOBAL INCIDENCE AND MORTALITY OF GENITOURINARY CANCERS WITH SOCIAL AND ECONOMIC DEVELOPMENT

Abstract

You have accessJournal of UrologyGeneral & Epidemiological Trends & Socioeconomics: Practice Patterns, Cost Effectiveness III1 Apr 2012410 ASSOCIATION OF GLOBAL INCIDENCE AND MORTALITY OF GENITOURINARY CANCERS WITH SOCIAL AND ECONOMIC DEVELOPMENT Sandip Prasad, Amit Patel, Alex Rosen, Ya-Chen Tina Shih, and Scott Eggener Sandip PrasadSandip Prasad Chicago, IL More articles by this author , Amit PatelAmit Patel Chicago, IL More articles by this author , Alex RosenAlex Rosen Chicago, IL More articles by this author , Ya-Chen Tina ShihYa-Chen Tina Shih Chicago, IL More articles by this author , and Scott EggenerScott Eggener Chicago, IL More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.476AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The relationship between global incidence and mortality rates for genitourinary malignancies and social and economic development have not been described. We describe worldwide contemporary age-standardized incidence (ASIR) and mortality (ASMR) rates for selected urologic cancers and their association with social and economic development metrics. METHODS We utilized the World Health Organization’s GLOBOCAN database to calculate ASIR and ASMR for bladder, kidney, prostate, and testicular cancer in 172 countries in 2008. The mortality-to-incidence ratio (MIR)—a proxy for 5-year survival rates—was calculated and the United Nations’ Human Development Index (HDI) used to estimate each country’s level of development. Linear regression analysis was performed to describe the relationship between HDI and MIR. RESULTS Global MIR was greatest for kidney cancer (0.40), intermediate for bladder (0.38) and prostate (0.27) cancer, and lowest for testicular cancer (0.20). For all four cancers (Table). MIR was highest in Africa—where 3 people died from a urologic cancer for every 4 new diagnoses—and lowest in North America. There was a strong inverse relationship between HDI and MIR for all cancers (Figure). with prostate cancer demonstrating the strongest association. Mortality-to-incidence ratio by geographic region for selected urologic cancers in 2008 Bladder Kidney Prostate Testis Africa 0.73 0.75 0.71 0.75 Asia 0.42 0.48 0.43 0.43 Australia/New Zealand 0.32 0.33 0.15 0.03 Caribbean 0.46 0.58 0.37 0.29 Central America 0.36 0.53 0.36 0.19 Central and Eastern Europe 0.42 0.44 0.38 0.23 Middle East and North Africa 0.59 0.67 0.63 0.50 North America 0.18 0.22 0.12 0.04 Northern Europe 0.35 0.39 0.21 0.03 South America 0.43 0.55 0.32 0.17 Western Europe 0.26 0.32 0.13 0.03 CONCLUSIONS Genitourinary cancer incidence and mortality rates vary widely throughout the world and may reflect differences in exposure to risk factors, health care access, patterns of screening, quality of care, diagnostic modalities used, and treatment options available. MIRs are highest in less developed nations and decline with increasing HDI, which suggest that social and economic disparities contribute to survival from urologic cancers worldwide. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e167-e168 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sandip Prasad Chicago, IL More articles by this author Amit Patel Chicago, IL More articles by this author Alex Rosen Chicago, IL More articles by this author Ya-Chen Tina Shih Chicago, IL More articles by this author Scott Eggener Chicago, IL More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...