402P Chemoradiation versus less intensive treatments in stage I squamous cell carcinoma of the anal canal (SCCA)

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Patients (pts) with stage I SCCA are underrepresented in randomized trials of chemoradiation (CRT). While most pts are cured with CRT, this may lead to significant acute and long-term adverse events. Thus less intensive treatments (LIT) for these pts could be as effective and less toxic than CRT. We compared the outcomes of real-world stage I SCCA pts treated with CRT versus LIT.