4 THE DIFFERENCE ON STRAIN AND STRAIN RATE PARAMETER OF LEFT VENTRICLE FUNCTION BETWEEN CONTROLLED HYPERTENSION AND UNCONTROLLED HYPERTENSION

Abstract

Background: Hypertension (HT) is associated with left ventricle (LV) diastolic and systolic dysfunction, even in patient with normal ejection fraction. Speckle tracking echocardiography (STE) has a high sensitivity in evaluating LV systolic and diastolic dysfunction. No published study evaluating the difference of LV systolic and diastolic function using STE between uncontrolled and controlled hypertension in Indonesia. Objective: This study sought to assess the difference of intrinsic left ventricle function between controlled HT and controlled HT. Methods: Cross-sectional study with 119 subjects consisting of 59 uncontrolled HT subjects and 60 controlled HT subjects, underwent STE study with global longitudinal strain (GLS) as a parameter to assess LV systolic function and strain rate as a parameter to assess LV diastolic function. Results: There is a significant difference of GLS between uncontrolled and controlled HT (−19,77 ± 3,10% vs −23,85 ± 2,25%, p < 0,0001). In subgroup analysis with left ventricle hypertrophy (LVH) also has a significant difference of GLS between uncontrolled (n = 36) and controlled HT (n = 25). (−19,50 ± 3,27% vs −23,50 ± 1,99%, p < 0,0001). There is no difference of E/SRE ratio between uncontrolled and controlled HT (46,48 (27,03–79,31 vs 45,35 (30,86–69,44), p = 0,539). There is significant difference of SRA between uncontrolled and controlled HT (1,40 (0,4–2,64) vs 1,19 (0,80–2,20), p < 0,0001). In subgroup of LVH and no-LVH, there is no difference of E/SRE ratio between uncontrolled and controlled HT (47,58 (27,03–79,31) vs 49,11 (32,33–67,42), p = 0,965; and 43,2 (30,36–65,63) vs 44,76 (30,86–69,44), p = 0,775 respectively). Conclusion: There is a significant different on GLS as a parameter of LV systolic intrinsic function between uncontrolled and controlled HT. There is no difference of E/SRE as a parameter of LV diastolic function between uncontrolled and controlled HT. But there is a significant difference of SRA between those groups.