Abstract
4-Picoline-2,2′:6′,2″-terpyridine-platinum(II) is shown in a ligation assay to unwind and so intercalate into DNA. Circular dichroism is used to determine an equilibrium binding constant of approximately 2 × 10 7 M −1 for the most stable binding mode of 4-picoline-2,2′:6′,2″-terpyridine-platinum(II) to poly[d(A-T) 2] with a site size of about 4 base pairs, and about 1 × 10 6 M −1 for a second binding mode with a site size of about 2 base pairs. Fluorescence spectroscopy provides further evidence for the strong equilibrium binding constant of 4-picoline-2,2′:6′,2″-terpyridine-platinum(II) in that it displaces ethidium bromide bound to DNA. The double positive charge on 4-picoline-2,2′:6′,2″-terpyridine-platinum(II), together with the intercalative binding mode is probably responsible for the large binding constant.
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