Abstract

A large number of independent factors may limit man's ability to perform physical work. At the onset of exercise, oxygen uptake increases gradually, and within a couple of minutes, it reaches a new level that is proportional to the performed work. Adipose tissue is the largest source of energy. The adrenergic neurohumoral system is considered to have a key position as a physiological regulator of the enhanced lipolysis in adipose tissue during exercise. One reason for this is that catecholamines are potent lipolytic agents in several species, including dog and man. The blood level of norepinephrine increases during physical activity, especially at workloads requiring large amounts of oxygen uptake. The level of circulating norepinephrine may predominantly reflect the activity in the sympathetic nerves as diffusion and overflow from the nerve terminals to the blood appear to be the principal inactivating mechanisms for the adrenergic transmitter, especially during exercise. Changes in the plasma concentration of epinephrine reflect the activity in the adrenal glands only. A change in the physical activity from rest to exercise elicits a rapid elevation of the glycerol concentration in plasma and an increased rate of free fatty acid turnover.

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