Abstract
•The respiratory centre in the medulla generates the respiratory rhythm using an oscillating network of groups of interconnecting neurones.•Many other diverse areas of the central nervous system influence respiratory control, and these connections are coordinated by the pons.•Irritant and stretch receptors in the lungs and diaphragm are involved in a series of reflex actions on the respiratory centre to influence respiratory activity.•Central chemoreceptors respond to changes in pH caused by alterations in carbon dioxide partial pressure, rapidly increasing ventilation in response to elevated arterial Pco2.•Peripheral chemoreceptors, principally in the carotid body, increase ventilation in response to reduced arterial Po2.
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