Abstract
Alginate hydrogels have a versatile implementation in tissue engineering and regeneration due to its scaffold-forming ability, whose structure, rigidity, and porosity can be modulated. It has excellent tissue biocompatibility, nonimmunogenic, and causes no thromboembolic complications. The extracellular matrix (ECM)-like properties of alginate renders it suitable for damaged tissue repair and regeneration. Arginine, glycine and aspartic acid (RGD) and heparin-binding peptide (HBP) introduction into alginate hydrogels assists cell adhesion properties and increases cell attachment for better cell-cell interaction and promotes differentiation. This chapter highlights some of the key studies that have been done using modified alginate hydrogel scaffolds for skin, articular cartilage, bone, and cardiac tissue repair and engineering.
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