Abstract
Abstract Two novel bioactive acetogenins, 4-acetyl annonacin (1) and 4-acetyl xylomaticin (2), were isolated from the leaves and twigs of Asimina longifolia K. (Annonaceae) by directing the fractionation with the brine shrimp lethality test. 1 and 2 each has a mono-tetrahydrofuran (THF) ring with two flanking hydroxyl groups and an α, β-unsaturated γ-lactone with a 4-acetoxyl. The presence of acetoxyl groups is a feature rarely found in the Annonaceous acetogenins. 1 and 2 showed potent and selective cytotoxicities among six human tumor cell lines.
Published Version
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