Abstract
The compound, 4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-4-methyl-2-phenyl-4,5-dihydrooxazole 2 was prepared in high yield, through nucleophilic substitution reaction of the O-tosyl oxazoline derivative 1, by heating in dimethyl sulfoxide (DMSO) and in presence of KOH as base. The structure of the synthesized compound was established on the basis of NMR spectroscopy (1H, 13C), MS data and elemental analysis.
Highlights
Five-membered heterocycles are a very important class of molecules because of their wide range of applications in various fields
In the continuation of our research concerning heterocyclic amino acids and their precursors [10,11,12,13,14], we described in this short note our results concerning the synthesis of a new pyrazole compound, 4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-4-methyl-2-phenyl-4,5-dihydrooxazole, an oxazolinic precursor of heterocyclic amino acids via nucleophilic substitution reaction of the (4-methyl-2-phenyl4,5-dihydrooxazol-4-yl)methyl-4-methylbenzenesulfonate and the 3,5-dimethyl-1H-pyrazole
Our synthesis strategy is based on the nucleophilic substitution of the O-tosyl group present in the oxazoline ring 1 with pyrazole nucleus
Summary
Five-membered heterocycles are a very important class of molecules because of their wide range of applications in various fields. Our synthesis strategy is based on the nucleophilic substitution of the O-tosyl group present in the oxazoline ring 1 with pyrazole nucleus. The O-tosylated oxazoline 1 obtained was subjected under the action of pyrazole using a superbase (KOH-DMSO) in order to synthesize the new biheterocyclic compound 2 (Scheme 1).
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