Abstract
Introduction. The need for arteriovenous fistula (AVF) as access to hemodialysis is increasing, but the failure rate of AVF maturity is also relatively high. Umbilical cord mesenchymal stem cells (MSCs) have anti-inflammatory properties that can occur in homeostasis, repair, and regeneration in pathological responses caused by vascular injury. This study aims to determine how administering cord mesenchymal stem cells (MSC) affects vascular maturity based on Doppler ultrasound examination in AVF rabbit models. Method. An experimental study proceeded using a local male rabbit (Lepus Domestica). The administration of umbilical cord mesenchymal stem cells was applied in situ on AVF and intravenously. Vascular maturation assessed using ultrasound was the variable of interest. The data obtained in this study were analyzed by parametric test using the one-way analysis of variance (ANOVA) test. Results. Analysis of vascular maturation based on vascular diameter showed a p–value of Conclusion. The administration of stem cells in situ affects the diameter of blood vessels and intravenously affects blood flow. Administration of stem cells in situ and intravenously may suppress vascular hyperplasia.
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