3P-0792 Nucleotidic receptor involvement in HDL endocytosis by human hepatic cells

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Caveolae, also known as “plasmalemmal vesicles,” are 50–100nm flask-shaped vesicular organelles located at the plasma membrane and within the Golgi complex. Caveolae play a central role in normal and pathogenic signaling events and represent a focal point for a variety of human diseases. Caveolin was first identified as a major v-Src substrate and later as a caveolar marker protein. Known to be an integral membrane phosphoprotein, caveolin could play the role of an adaptor molecule, linking other caveolar components to cytoplasmic signaling molecules. The role of caveolae in the transcellular transport of protein was studied in endothelial cells. A series of both large and small fluid-phase tracer molecules were transported across capillary endothelial cells via caveolae.