Abstract
3H-Δ 9-Tetrahydrocannabinol ( 3H-Δ 9-THC), 3H-cannabidiol ( 3H-CBD) and 3H-cannabinol ( 3H-CBN) were administered (1 mg/kg) to male rats which were decapitated either 0.5, 1, 15, 30 or 90 min later. The plasma concentration was similar for all cannabinoids throughout the time course. After 5 min greater than 80% of the plasma radioactivity in each treatment was due to metabolites. Radioactivity rapidly entered brain after the administration of 3H-CBD, 3H-CBN, and 3H-Δ 9-THC. The concentrations of unchanged 3H-CBD and 3H-CBN in whole brain were higher than that of 3H-Δ 9-THC 5 min after administration. Regional distribution of radioactivity in the brain after 5 min was similar for all three cannabinoids, the only significant difference being in hypothalamus. Coadministration of 3H-Δ 9-THC with a five-fold excess of either CBD or Δ 9-THC did not produce any significant alteration in the levels of radioactivity in brain or plasma 5 min after their injection. The difference in behavioral activity of Δ 9-THC, CBD and CBN cannot be explained by penetrability or regional distribution in the brain.
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