Abstract
Levels of radioactivity in the brain stem, cerebellum, temporal cortex and frontal cortex of birds tolerant to δ 9-tetrahydrocannabinol (δ 9-THC) did not differ significantly from levels in the same tissue of nontolerant birds after administration of 3H-δ 9-THC. Levels of radioactivity in the lungs of both tolerant and nontolerant birds were similar to the levels of radioactivity in the brain areas after 3H-δ 9-THC; however, higher levels of radioactivity were found in the livers of both groups of birds than were found in the brains. Approximately 0·1 per cent of the total dose of radioactivity was in the brain of both tolerant and nontolerant birds 2·5 hr after injection. When pigeons were injected repeatedly (seven times in 2 weeks) with 3H-δ 9-THC, there was some accumulation of radioactivity in brain and lung, and an even greater accumulation in liver. These data suggest that tolerance to δ 9-THC in pigeons is not due to a decreased concentration of total cannabinoids in the brain.
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