3D strain analysis of trabecular bone within the osteoarthritic humeral head subjected to stepwise compressive loads

Abstract

Understanding the local mechanical properties of trabecular bone at the humeral head-neck junction is essential for the safe design of stemless humeral head implants. Recent advancements in mechanical testing coupled with volumetric imaging have allowed for the ability to quantify full-field strain distributions throughout trabecular bone. Within this study, digital volume correlation (DVC) was applied to micro-computed tomography images to investigate the local load carrying characteristics of trabecular bone within osteoarthritic (OA) humeral heads subjected to stepwise loading. A multi-pegged indenter was used to transfer loads from a custom-fabricated loading apparatus to trabecular bone on the resection surface of OA humeral head osteotomies retrieved from patients undergoing total shoulder arthroplasty (TSA). In regions of trabecular bone that eventually fractured, third principal strains were significantly higher (95th percentile third principal strain = −12,558 μstrain, p < 0.001) compared to regions that did not fracture (95th percentile third principal strain = −7,806 μstrain). As well, bone volume fraction (p = 0.012), trabecular separation (p = 0.014), and trabecular number (p = 0.007) were found to influence the likelihood of trabecular bone fracture. Collectively, this work has led to a deeper understanding of the local load carrying characteristics of trabecular bone specific to patients receiving TSA for osteoarthritis.