Abstract
Additive manufacturing, commonly referred to as 3D printing, is a technology that builds three-dimensional structures and components layer by layer. Bioprinting is the use of 3D printing technology to fabricate tissue constructs for regenerative medicine from cell-laden bio-inks. 3D printing and bioprinting have huge potential in revolutionizing the field of tissue engineering and regenerative medicine. This paper reviews the application of 3D printing and bioprinting in the field of pediatrics.
Highlights
Category Vat PolymerizationMaterial Jetting Binder JettingMaterial ExtrusionPowder Bed Fusion Sheet Lamination Directed Energy Deposition DescriptionLiquid photopolymer in a vat is selectively cured by light-activated polymerizationDroplets of build material are selectively depositedLiquid bonding agent is selectively deposited to join powder materialsMaterial is selectively dispensed through a nozzle or orificeThermal energy selectively fuses regions of a powder bed Sheets of material are bonded to form an object
Bioprinting is the use of 3D printing technology to fabricate tissue constructs for regenerative medicine from cell-laden bio-inks. 3D printing and bioprinting have huge potential in revolutionizing the field of tissue engineering and regenerative medicine
This paper reviews the application of 3D printing and bioprinting in the field of pediatrics
Summary
Liquid photopolymer in a vat is selectively cured by light-activated polymerization. Focused thermal energy is used to fuse materials by melting as they are being deposited. Bioprinting is defined as the use of 3D printing technology with materials that incorporate viable living cells, e.g., to produce tissue for reconstructive surgery [2]. Laser-assisted bioprinting focuses laser pulses on to the donor slide, creating high pressure to propel droplets of cell-laden hydrogel on to the collector slide. Inkjet printing ejects droplets of biopolymer or cell-laden hydrogels through a nozzle by either thermal energy application (electrically heating to produce vapor bubbles that forces droplets to come (eleocutrtitcharlolyughheathteinngotzozlpe)roodr uacpeievzaopeloerctbriucbabctluesattohra(tacfoturacteiosndorof pplieeztsoetolecctorimc ceryosuttaltshbroyuagphpltyhinegnozzle) or aelpeciterzicoaelleecnterricgyacatut ahtoigrh(afcrteuqauteioncnieosf).pEiexztroueslieocntriocrcrryosbtoatlisc bdyisappepnslyinigngbeiolepcrtirnitcearsl eenxetrgudyeat high freqbuioepnocliyems)e.rEs xotrrucseilol-nladoernrohbyodtriocgdeilsptehnrosuingghbtihoepnrionztzelresbeyxtarpupdleyibnigopaiorlypmresesrusroer(cpenlel-ulmadaetinc)hoyrdrogels thromuegchatnhiecanlosyzsztleembsy(paipsptolnyionrgscarierwp)r.eTshseurpero(spannedumcoantsico)f othremseetchhraeenitcyaplesyosftbeimopsr(inptiisntgonproorcesscsreesw). On the othmerahtearniadls,,foasr hthaeridr tiinstseunedsedsuucsheaiss bfoornesu, mrgaertyeripallasnwniintgh banedttetrramineinchg.anHiocawlepvreor,pethretiesselaercetiopnreofef rred to meet the functional tissue requirement. Synthetic polymers such as Polycaprolactone (PCL) and naturally occurring minerals such as hydroxyapatite (HA) are used for bone tissue engineering [6,7,8]
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