Abstract
Skin is the largest organ of the human body. In recent years, concern regarding the cosmetics area has increased, and research studies on anti-aging therapy or cosmetics have been rapidly conducted. Skin cells are not only changing its shape but also its physical properties during the epidermal skin turnover process. Computational simulation can be useful in further understanding the mechanisms of skin formation. We propose a particle model that can handle complex biological phenomena, including cell interactions and is a suitable method for simulating skin formation. The particle model was applied to simulate three-dimensional skin formation accompanied by proliferation and cornification of skin cells. The simulation results represented and reproduced the epidermal skin turnover phenomenon.
Highlights
Skin is the largest organ of the human body
This study developed an analytical method for the formation and turnover process in skin using a particle model
At the bottom of the skin, the volume conservation force is dominant as the cells move upward, spring force gradually emerges and becomes dominant at the corneum surface
Summary
Skin is the largest organ of the human body. Skin cells change its shape and its physical properties during the turnover process. Computational simulation can be useful in further understanding the mechanisms of skin development, and several models have been proposed [2]-[5]. We propose a particle model that can handle complex biological phenomena, including cell interactions such as cell division, motion, deformation, and transition [6] [7]. It is a suitable method for simulating skin formation [7]-[9]
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